Human Cytomegalovirus Latency: Targeting Differences in the Latently Infected Cell with a View to Clearing Latent Infection
Figure 5
HCMV genes expressed during latency. The HCMV genome is comprised of two terminal repeats (TR), two internal repeats (IR), a unique long region (UL), and a unique short region (US). Genes expressed during latency identified so far are boxed and include US28 [66], UL82as/LUNA [67], latency-associated viral IL-10/UL111a [68], and UL122/123 CMV latency transcripts (CTLs) [53] regions of the genome. The region of the genome termed ULb’ is a segment of UL which becomes lost during extensive passaging of laboratory strains and two genes identified during latency are located in ULb’ UL144 [46] and UL138 [59].
