Human Cytomegalovirus Latency: Targeting Differences in the Latently Infected Cell with a View to Clearing Latent Infection

Figure 6

GATA2 may be a key regulator of HCMV latency Downregulation of the human miRNA hsa-miR-92a leads to a concomitant upregulation of the myeloid transcription factor GATA2 [45]. GATA2 is important during myeloid differentiation [74–77] and can drive the expression of latency-associated genes UL144 and LUNA [46, 49]. GATA2 can also drive the expression of cellular IL-10 which in turn can energize CD4+ cytotoxic T cells and act as a prolife signal for CD34+ cells [78].