Table of Contents
New Journal of Science
Volume 2014, Article ID 390241, 27 pages
http://dx.doi.org/10.1155/2014/390241
Review Article

Candida Immunity

Mucosal and Salivary Biology Division, King’s College London Dental Institute, King’s College London, London SE1 1UL, UK

Received 9 February 2014; Accepted 5 June 2014; Published 25 August 2014

Academic Editor: Mohd Roslan Sulaiman

Copyright © 2014 Julian R. Naglik. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The human pathogenic fungus Candida albicans is the predominant cause of both superficial and invasive forms of candidiasis. C. albicans primarily infects immunocompromised individuals as a result of either immunodeficiency or intervention therapy, which highlights the importance of host immune defences in preventing fungal infections. The host defence system utilises a vast communication network of cells, proteins, and chemical signals distributed in blood and tissues, which constitute innate and adaptive immunity. Over the last decade the identity of many key molecules mediating host defence against C. albicans has been identified. This review will discuss how the host recognises this fungus, the events induced by fungal cells, and the host innate and adaptive immune defences that ultimately resolve C. albicans infections during health.