Candida Immunity

Table 1

Fungal pattern recognition receptors.

PRR	Location	Recognition molecules	Role in fungal response
TLRs
TLR1/2	Surface	Zymosan/β-glucans?	Probably
TLR2	Surface	Phospholipomannan; zymosan	Yes
TLR2/6	Surface	Zymosan/β-glucans?	Probably
TLR3	Endosomal	dsRNA	Possibly
TLR4	Surface/cytoplasmic	-linked mannan	Yes
TLR9	Endosomal	Unmethylated CpG fungal DNA	Yes
C-type lectins
Dectin-1	Surface	β-1,3 glucan; mannan; zymosan	Yes
Dectin-2/3	Surface	High mannose structures; α-mannan	Yes
Mannose receptor	Surface	-linked mannan, N-acetylglucosamine	Yes
Mincle	Surface	α-Mannan	Probably
DC-SIGN	Surface	High (N-linked) mannose structures	Possibly
Galectins	Cytoplasm/nucleus; extracellular	β-1,2 mannosides (variety of complex N-glycans)	Probably
NLRs
NLRP3	Cytoplasmic	Variable (zymosan; β-glucan)?	Yes
NLRC4	Cytoplasmic	Variable (zymosan; β-glucan)?	Yes

Table adapted from [63].