Nucleoporin Gene Fusions and Hematopoietic Malignancies
Figure 2
Molecular features of nucleoporins. (a) Nup98 is generated by autocleavage of the Nup98-Nup96 and Nup98 precursor, respectively. Cleavage occurs due to an intrinsic peptidase activity (indicated by the white arrow heads). (b) Schematic representation of Nup98, Nup214, and Nup358 domain organization and their binding partners. P/S: proline-serine rich; CC: coiled-coil; LRR: leucine-rich region; RB: Ran-binding domain; ZNF: zinc-finger domain; KB: kinesin-binding domain; IR: internal repeats (E3 ubiquitin ligase domain); CY: cyclophilin A homology domain.
