New Journal of Science / 2014 / Article / Tab 2

Review Article

Nucleoporin Gene Fusions and Hematopoietic Malignancies

Table 2

NUP214 and NUP358 fusion partner.

Nucleoporin genePartner geneTranslocationPartner function DiseaseReference

NUP214SETdel(9)(q34)Apoptosis, cell cyle, migration, nucleosome assembly, inhibitor of PP2AT-ALL, AML[150, 153, 156158, 160, 167, 273, 274]
DEKt(6; 9)(p22; q34) DNA-binding, transcriptionAML, MDS[150, 156, 159, 161, 162, 274, 275]
ABL1Amp(9q34)Tyrosine kinaseT-ALL[151, 154, 155, 158, 164166, 276278]
SQSTM1NFκB activation T-ALL[152]

NUP358ALKinv2(p23; q13)KinaseAML, MDS, IMT[204211]
FGFR1t(2; 8)(q12; p11)Tyrosine receptor kinaseMDS[203]

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