Regulations of P-Glycoprotein/ABCB1/MDR1 in Human Cancer Cells

Table 1

MicroRNAs regulate MDR1 mRNA expression.

miRNA	Direct regulation; (binding to the MDR1 3′-UTR)	Indirect regulation; (target gene)	MDR1 mRNA	Cell line	Reference
miR-451	✓		↑	2780DX5, KB-V1, MCF-7,; Cancer stem cells	[47–49]
miR-27a	✓		↑	2780DX5, KB-V1, K562/DOX, NB4/R2, HL-60/DOX	[47, 50]
		✓ (HIPK2)		BEL/5-FU, A2780/Taxol	[51, 52]
miR-508-5p	✓		↑	SGC7901/VCR	[53]
miR-331-5p	✓		↑	K562/DOX, NB4/R2, HL-60/DOX	[50]
miR-298	✓		↑	MDA-MB-231-R	[54]
miR-145	✓		↑	HEK293, Caco-2	[55]
miR-137		✓ (YB-1)	↑	MCF-7/ADR	[56]
miR-200c		✓ (ZEB1/2?)	↑	MCF-7/ADM, MDA-MB-231	[57]
miR-122		✓ (Unknown)	↑	Hep3B, HepG2, Huh7, PLC/PRF/5	[58]
miR-138		✓ (Unknown)	↑	HL-60/VCR	[59]
miR-19a/b		✓ (PTEN)	↑	SKOV3/CIS	[60]
miR-130a		✓ (PTEN)	↓	SGC7901/VCR, SGC7901/ADR	[61]