Genetic Dissection of the Physiological Role of Skeletal Muscle in Metabolic Syndrome
Figure 2
Schematic diagram of activation of slow fiber-specific and oxidative metabolic genes in skeletal muscle fiber type plasticity. Intracellular Ca2+ levels are raised by tonic-low frequency (slow type) stimulation. An arrow indicates activation and a bar with a horizontal line indicates suppression. The transcription factors NFAT, Mef2, and PGC-1α activate transcription of target genes which define fiber type properties.
