Myocardial Reprogramming Medicine: The Development, Application, and Challenge of Induced Pluripotent Stem Cells

Figure 3

The model of direct reprogramming of fibroblasts into cardiomyocytes in infarct heart. The transient overexpression of cardiac specific TFs, GMT, is able to generate cardiac lineage-specific cells directly from somatic cells. This process “skipping pluripotency” does not require transition through a pluripotent intermediate, immensely eliminating the risk of tumorigenicity.