Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 1
Reported pharmacokinetic profile of baicalein and baicalin after three oral doses of baicalein and one i.v. dose of baicalein (
) [
4].
| | Group (mg/kg) | Parameter | AUC (μg/L h) | (μg/L) | (h) | (h) | MRT (h) | (%) |
| | 50 | Baicalein | 454.3 121.7 | 167.3 73.2 | 1.6 0.3 | 1.4 1.0 | 2.9 0.3 | 23.0 | | Baicalin | 18366.3 4796.3 | 4216.7 1380.7 | 3.8 0.5 | 4.1 0.8 | 5.1 0.4 | |
| | 150 | Baicalein | 1156.1 205.2 | 318.4 51.8 | 1.4 0.6 | 6.4 3.6 | 5.9 0.8 | 19.9 | | Baicalin | 47654.9 15208.0 | 7194.7 4984.5 | 4.0 0.8 | 4.1 0.5 | 7.2 2.5 | |
| | 500 | Baicalein | 2526.9 1537.3 | 612.5 316.0 | 2.3 1.2 | 13.4 9.5 | 6.2 1.5 | 13.1 | | Baicalin | 104717.4 52674.3 | 13687.0 2215.8 | 3.5 0.6 | 6.5 3.6 | 9.0 4.1 | — |
| | i.v. 10 | Baicalein | 7421.5 1079.9 | 30409.2 4610.7 | 0.033 | 4.8 5.0 | 0.4 0.2 | — | | Baicalin | 4389.7 860.4 | 6146.6 3363.4 | 0.083 | 0.9 0.2 | 3.3 0.4 | — |
|
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