A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 17

Pharmacokinetic parameters of PD and PD3 after intravenous (25 mg/kg) or oral administration of PD (500 mg/kg) to rats () [19].

Parameter	PD	PD3
Intravenous
AUC (μg·h/mL)	11.42 3.43	1.96 0.50
(h)	1.99 0.41	3.55 0.87
MRT (h)	1.58 0.41	2.85 0.77
(L/kg)	3.59 1.28	35.32 18.69
CL (L/h/kg)	2.32 0.90	11.84 27.77
Oral
AUC (μg·h/mL)	0.66 0.36	0.53 0.31
(h)	6.23 1.84	6.20 1.05
(μg/mL)	0.22 0.22	0.20 0.24
(h)	0.75 (0.17–3)	0.48 (0.11–1.61)

Data are mean SD (standard deviation). Median (ranges).