A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 18

Pharmacokinetic parameters of TB-II in rats following intragastric administration of timosaponins, timosaponins-Huangbai alkaloids 1 : 1 and 1 : 3 mixtures [20].

Parameters	Timosaponins ()			Timosaponins-Huangbai alkaloids 1 : 3 (TB-II 300 mg/kg, )	Timosaponins-Huangbai alkaloids 1 : 1 (TB-II 300 mg/kg, )
	TB-II 150 mg/kg	TB-II 300 mg/kg	TB-II 600 mg/kg
(μg/L)	511.4 556.7	433.9 310.5	2182 1417	2621 1432	4034 2658
(h)	1.04 1.18	2.38 1.28	1.92 0.80	2.10 0.55	3.40 0.55
(h)	4.12 3.11	5.47 3.60	2.45 1.32	2.50 2.09	1.01 0.11
AUC (μg h/L)	866.6 779.7	1026 491	4249 2207	5013 2357	9713 5151
AUC (μg h/L)	1092 780	1010 520	4267 2204	5102 2315	9730 5157
MRT (h)	7.65 5.98	6.10 3.22	3.46 0.80	3.30 0.84	3.73 0.24

< 0.05 versus oral administration of timosaponins (TB-II 300 mg/kg).