New Journal of Science / 2016 / Article / Tab 18

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 18

Pharmacokinetic parameters of TB-II in rats following intragastric administration of timosaponins, timosaponins-Huangbai alkaloids 1 : 1 and 1 : 3 mixtures [20].

ParametersTimosaponins ()Timosaponins-Huangbai alkaloids 1 : 3 (TB-II 300 mg/kg, ) Timosaponins-Huangbai alkaloids 1 : 1 (TB-II 300 mg/kg, )
TB-II 150 mg/kgTB-II 300 mg/kgTB-II 600 mg/kg

(μg/L)511.4 556.7433.9 310.52182 14172621 14324034 2658
(h)1.04 1.182.38 1.281.92 0.802.10 0.553.40 0.55
(h)4.12 3.115.47 3.602.45 1.322.50 2.091.01 0.11
AUC (μg h/L)866.6 779.71026 4914249 22075013 23579713 5151
AUC (μg h/L)1092 7801010 5204267 22045102 23159730 5157
MRT (h)7.65 5.986.10 3.223.46 0.803.30 0.843.73 0.24

< 0.05 versus oral administration of timosaponins (TB-II 300 mg/kg).