New Journal of Science / 2016 / Article / Tab 19

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 19

Pharmacokinetic parameters of TA-III in rats following intragastric administration of timosaponins, timosaponins-Huangbai alkaloids 1 : 1 and 1 : 3 mixtures, (1.17 mg TA-III/kg body weight) [20].

Parameters Timosaponins ()Timosaponins-Huangbai alkaloids 1 : 1 (TA-III 1.17 mg/kg, )Timosaponins-Huangbai alkaloids 1 : 3 (TA-III 1.17 mg/kg, )
TA-III 0.59 mg/kgTA-III 1.17 mg/kgTA-III 2.34 mg/kg

(μg/L)18.24 5.8125.10 4.0954.62 12.1538.63 20.4127.76 13.77
(h)6.60 2.975.50 3.336.33 1.977.60 2.618.33 2.34
(h)6.68 1.666.61 3.125.51 1.2410.80 3.349.91 2.81
AUC (μg h/L)180.5 64.4248.5 62.6505.8 155.2633.8 313.2434.9 223.3
AUC (μg h/L)208.4 59.7290.7 58.7547.9 178.4711.1 344.3491.3 259.7
MRT (h)12.18 1.1312.54 3.4410.33 1.4718.01 3.6017.30 2.94

< 0.05 versus oral administration of timosaponins (TA-III 1.17 mg/kg).