A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

<div class="floats-full-page floats-full-page-other"><h2>Table 20</h2><div class="floats-full-page-caption">Pharmacokinetic parameters after oral administration of Aralia-saponin V, Aralia-saponin VI, and the extract of <i>A. elata</i> leaves [<a href="../../7830367/#B21">21</a>].</div><div class="floats-full-page-content"><table class="table-group" id="tab20"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr /></td></tr><tr class="thead"><td class="align_left" rowspan="2">Parameters</td><td class="align_center" rowspan="2">Aralia-saponin V</td><td class="align_center" rowspan="2">Aralia-saponin<br />VI</td><td class="align_center" colspan="2"> Extract of Aralia  elata leaves</td></tr><tr class="thead"><td class="align_center">Aralia-saponin<br />V</td><td class="align_center">Aralia-saponin<br />VI</td></tr><tr><td class="thead-hr" colspan="5"><hr /></td></tr><tr><td class="align_left"><svg height="11.9316pt" id="M768" style="vertical-align:-3.2957pt" version="1.1" viewbox="-0.0498162 -8.6359 25.3434 11.9316" width="25.3434pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M645 631C614 643 545 666 457 666C215 666 23 519 23 283C23 90 158 -16 337 -16C412 -16 489 2 522 10C543 39 590 127 606 167L580 181C519 89 459 18 348 18C201 18 122 136 122 287C122 464 244 632 435 632C544 632 602 595 608 472L639 475C643 526 645 581 645 631Z" id="g113-68"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="668" vert-adv-y="668"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.619,3.132)"><path d="M810 0V30C751 35 744 40 744 106V296C744 396 694 451 614 451C583 451 558 438 537 425C512 409 485 391 454 368C434 420 390 451 342 451C309 451 285 439 260 424C228 405 206 387 185 372V453C141 434 90 421 43 413V386C102 378 105 373 105 309V106C105 41 96 35 29 30V0H243V30C194 35 185 41 185 106V335C216 360 256 389 297 389C357 389 384 348 384 275V106C384 41 374 35 312 30V0H530V30C475 35 465 41 465 104V294C465 313 464 324 463 336C502 367 539 389 576 389C637 389 663 346 663 274V109C663 41 653 35 593 30V0H810Z" id="g58-107"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="834" vert-adv-y="834"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,16.181,3.132)"><path d="M442 39L431 68C420 63 406 57 394 57C377 57 359 71 359 118V301C359 353 349 393 314 424C291 443 261 451 230 451C171 438 107 401 79 381C59 366 46 355 46 340C46 316 72 295 91 295C106 295 117 303 122 319C131 350 139 371 152 384C163 397 178 404 197 404C246 404 281 365 281 293V278C260 262 186 232 124 213C69 194 41 161 41 112C41 47 92 -12 163 -12C195 -12 243 25 283 51C288 35 293 22 308 7C319 -4 339 -12 354 -12L442 39ZM281 87C262 68 226 51 199 51C169 51 129 74 129 126C129 162 151 181 190 198C211 208 259 229 281 240V87Z" id="g58-95"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="449" vert-adv-y="449"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,20.267,3.132)"><path d="M482 0V30C420 38 407 48 370 103L273 248C308 299 331 332 352 357C387 397 401 404 463 409V439H277V409C318 405 324 400 307 369C290 337 270 307 251 279L194 367C175 396 180 402 220 409V439H18V409C74 401 87 395 117 349L204 213C173 168 147 130 119 95C78 46 67 38 5 30V0H195V30C144 38 143 47 162 79C181 112 202 149 225 181L297 70C314 43 307 35 264 30V0H482Z" id="g58-118"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="481" vert-adv-y="481"></glyph.data></g></svg> (ng/mL)</td><td class="align_center">161.8 ± 20.19</td><td class="align_center">188.55 ± 35.35</td><td class="align_center">174.5 ± 5.21</td><td class="align_center">192.59 ± 18.7</td></tr><tr><td class="align_left"><svg height="12.2578pt" id="M769" style="vertical-align:-3.29568pt" version="1.1" viewbox="-0.0498162 -8.96212 23.8949 12.2578" width="23.8949pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z" id="g113-85"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="637" vert-adv-y="637"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.176,3.132)"><path d="M810 0V30C751 35 744 40 744 106V296C744 396 694 451 614 451C583 451 558 438 537 425C512 409 485 391 454 368C434 420 390 451 342 451C309 451 285 439 260 424C228 405 206 387 185 372V453C141 434 90 421 43 413V386C102 378 105 373 105 309V106C105 41 96 35 29 30V0H243V30C194 35 185 41 185 106V335C216 360 256 389 297 389C357 389 384 348 384 275V106C384 41 374 35 312 30V0H530V30C475 35 465 41 465 104V294C465 313 464 324 463 336C502 367 539 389 576 389C637 389 663 346 663 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409V439H277V409C318 405 324 400 307 369C290 337 270 307 251 279L194 367C175 396 180 402 220 409V439H18V409C74 401 87 395 117 349L204 213C173 168 147 130 119 95C78 46 67 38 5 30V0H195V30C144 38 143 47 162 79C181 112 202 149 225 181L297 70C314 43 307 35 264 30V0H482Z" id="g58-118"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="481" vert-adv-y="481"></glyph.data></g></svg> (h)</td><td class="align_center">1.08 ± 0.19</td><td class="align_center">0.88 ± 0.13</td><td class="align_center">1.04 ± 0.09</td><td class="align_center">0.88 ± 0.13</td></tr><tr><td class="align_left"><span style="width: 13.8266ptpx;"><svg height="11.9316pt" id="M770" style="vertical-align:-3.2957pt" version="1.1" viewbox="-0.0498162 -8.6359 13.8266 11.9316" width="13.8266pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M743 650H503L496 622L527 618C563 613 564 603 532 573C449 495 371 431 323 392C301 374 272 355 246 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class="align_center">0.09 ± 0.01</td><td class="align_center">0.16 ± 0.07</td><td class="align_center">0.09 ± 0.02</td></tr><tr><td class="align_left"><svg height="12.4933pt" id="M771" style="vertical-align:-4.679481pt" version="1.1" viewbox="-0.0498162 -7.81382 17.7973 12.4933" width="17.7973pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z" id="g113-117"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="341" vert-adv-y="341"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,4.368,3.132)"><path d="M389 0V32C297 38 291 46 291 118V635C234 613 175 595 109 583V556L161 554C203 552 207 547 207 497V118C207 46 201 38 110 32V0H389Z" id="g50-50"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.8,3.132)"><path d="M381 704H317L48 -163H112L381 704Z" id="g50-48"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="429" vert-adv-y="429"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,12.707,3.132)"><path d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z" id="g50-51"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg> (h)</td><td class="align_center">7.33 ± 2.59</td><td class="align_center">7.45 ± 0.61</td><td class="align_center">4.92 ± 1.89</td><td class="align_center">7.92 ± 1.67</td></tr><tr><td class="align_left">AUC<svg height="8.06455pt" id="M772" style="vertical-align:-4.67949pt" version="1.1" viewbox="-0.0498162 -3.38506 19.5053 8.06455" width="19.5053pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,3.132)"><path d="M309 -142C211 -61 151 99 151 271S210 601 309 683L288 710C141 611 75 451 75 272V271C75 90 141 -72 288 -169L309 -142Z" id="g50-41"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,3.258,3.132)"><path d="M245 635C92 635 37 457 37 312C37 149 91 -12 244 -12C395 -12 449 166 449 312C449 469 395 635 245 635ZM243 598C332 598 358 454 358 312C358 173 334 26 245 26C158 26 128 174 128 313S152 598 243 598Z" id="g50-49"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.689,3.132)"><path d="M469 201V252H50V201H469Z" id="g190-178"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="520" vert-adv-y="520"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,12.439,3.132)"><path d="M329 433H203L239 587L230 596L147 534L123 433H57L30 395L34 388H115L61 129C37 16 59 -12 85 -12C147 -12 222 58 260 98L241 125C212 95 160 62 144 62C132 62 127 71 138 126L192 386L305 394L329 433Z" id="g50-117"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="347" vert-adv-y="347"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,15.597,3.132)"><path d="M283 271C283 451 220 610 70 710L48 683C146 603 207 443 207 271S149 -59 48 -142L70 -169C220 -67 283 90 283 271Z" id="g50-42"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g></svg> (ng/mL/h)</td><td class="align_center">796.0 ± 135.6</td><td class="align_center">932.45 ± 95.92</td><td class="align_center">915.7 ± 79.7</td><td class="align_center">1024.69 ± 112.5</td></tr><tr><td class="align_left">AUC<svg height="8.06455pt" id="M773" style="vertical-align:-4.67949pt" 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vert-adv-y="520"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,12.439,3.132)"><path d="M1000 227C1000 351 905 451 780 451C658 451 590 380 530 279C465 385 388 451 261 451C168 451 38 376 38 210C38 98 121 -12 261 -12C381 -12 448 59 508 160C573 53 652 -12 780 -12C879 -12 1000 64 1000 227ZM485 199C434 109 370 25 271 25C188 25 133 117 133 241C133 355 189 414 249 414C357 414 426 302 485 199ZM903 204C903 70 852 25 790 25C681 25 611 136 552 240C603 330 669 414 768 414C855 414 903 321 903 204Z" id="g50-30"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="1038" vert-adv-y="1038"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,21.885,3.132)"><path d="M283 271C283 451 220 610 70 710L48 683C146 603 207 443 207 271S149 -59 48 -142L70 -169C220 -67 283 90 283 271Z" id="g50-42"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g></svg> (ng/mL/h)</td><td class="align_center">1156.9 ± 286.6</td><td class="align_center">1306.74 ± 160.24</td><td class="align_center">1210.3 ± 211.4</td><td class="align_center">1516.73 ± 197.68</td></tr><tr><td class="align_left">LLOQ (ng/mL)</td><td class="align_center">5.70</td><td class="align_center">6.15</td><td class="align_center">—</td><td class="align_center">—</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr" /></td></tr></table></td></tr></table></div></div>

Table 20 | A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

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Table 20: A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

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Table 20

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A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

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