New Journal of Science / 2016 / Article / Tab 21

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 21

Pharmacokinetic parameters of Escin Ia in rats after i.v. administration of the drug () [22].

Parameters0.5 mg/kg1.0 mg/kg2.0 mg/kg

(ng/mL)228074854362 129811,220 2330
(h)7.5 2.19.6 1.912.2 1.7
AUC (ng h/mL)10,036 420312,989 310129,156 6495
AUC (ng h/mL)10,145 427013,185 330229,941 6753
CL (mL/min/kg)4.82 2.136.05 1.955.81 1.30
(L/kg)2.86 1.395.02 3.856.16 3.53
MRT (h)5.46 1.545.39 0.8806.29 1.16