Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 22
Pharmacokinetic parameters of isoescin Ia in rats after i.v. administration of Escin Ia (
) [
22].
| | Parameters | 0.5 mg/kg | 1.0 mg/kg | 2.0 mg/kg |
| | (ng/mL) | 584 172 | 875 196 | 2058 385 | | (h) | 5.7 2.0 | 4.5 1.2 | 3.5 0.4 | | (h) | 8.1 0.8 | 7.9 1.51 | 0.4 1.8 | | AUC (ng h/mL) | 9879 4446 | 14,094 4580 | 32,401 8791 | | AUC (ng h/mL) | 10,519 4787 | 14,431 4969 | 33,832 9336 | | AUC ratio of isoescin Ia/Escin Ia | 0.99 0.25 | 1.12 0.06 | 1.11 0.10 |
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