New Journal of Science / 2016 / Article / Tab 22

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 22

Pharmacokinetic parameters of isoescin Ia in rats after i.v. administration of Escin Ia () [22].

Parameters0.5 mg/kg1.0 mg/kg2.0 mg/kg

(ng/mL)584 172875 1962058 385
(h)5.7 2.04.5 1.23.5 0.4
(h)8.1 0.87.9 1.510.4 1.8
AUC (ng h/mL)9879 444614,094 458032,401 8791
AUC (ng h/mL)10,519 478714,431 496933,832 9336
AUC ratio of isoescin Ia/Escin Ia0.99 0.251.12 0.061.11 0.10