A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 30

Pharmacokinetic parameters of matrine after i.v. and oral administration of matrine in rat plasma () [29].

Parameter	i.v.	p.o.
(ng/mL)	—	94.6 38.6
(min)	—	105 30
AUC (min ng/mL)	108,637 11,801	18,453 5885
AUC (min ng/mL)	108,794 11,712	18,593 5931
(min)	142 79	92 32
(L/min)	0.0060 0.0030	0.0081 0.0023
(mL/kg)	3704 1874	2433 1668
CL (mL/min/kg)	18.6 2.0	19.7 5.5
Bioavailability (%)	—	17.1 5.4