Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 32
Pharmacodynamic parameters of Dau and DS after i.v. administration in beagle dogs (dose 6 mg/kg and
) [
30].
| | Parameters | /h−1 | /% | /mg·L−1 | | | DS | Dau | DS | Dau | DS | Dau | DS | Dau |
| | HR (min−1) | 5.4 2.2 | 6.0 0.8 | 59 30 | 34 12 | 0.42 0.15 | 0.29 0.04 | 4.2 1.5 | 2.5 0.4 | | SBP (kPa) | 5.1 1.6 | 4.9 1.2 | 75 24 | 32 6 | 0.40 0.12 | 0.33 0.15 | 3.7 2.1 | 1.9 0.9 | | LVSP (kPa) | 5.5 2.4 | 7 3 | 72 44 | 33 9 | 0.34 0.07 | 0.32 0.04 | 3.5 2.6 | 3.6 2.0 | | (kPa/s) | 4.0 1.8 | 4.6 1.3 | 66 8 | 59 23 | 0.28 0.06 | 0.29 0.06 | 3.4 1.9 | 3.8 2.5 |
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