A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 39

Pharmacokinetic parameters of GA and PCA in rats after oral administrations of P. capitatum extract [37].

Parameter	(min)	(min)	(ng/mL)	AUC (ng min/mL)	AUC (ng min/mL)	(L/kg)	CL (L/kg/min)
GA
Low dose	128.52	40	246.24 227.13	41,731.12	11,016,269.07	9.3	5.02 × 10^−2
Middle dose	93.72	100	477. 70 231.86	93,537.54	16,162,323.5	11.2	8.32 × 10^−2
High dose	114.70	100	806.27 433.21	190,936.39	40,927,327.16	13.1	7.93 × 10^−2
PCA
Low dose	42.81	30	15.73 5.31	523.90	943.88	58.9	0.954
Middle dose	90.15	20	24.66 14.63	1561.26	2943.38	119.3	0.917
High dose	49.80	40	30.72 411.77	3409.57	4222.79	128.8	1.128