A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 40

Pharmacokinetic parameters after oral administration of chlorogenic acid (50.0 mg/kg) and extract of S. lyratum (equal to 50.0 mg/kg chlorogenic acid) (/group) [38].

Parameters	Chlorogenic acid (p.o.)	Extract of S. lyratum (p.o.)
AUC (mg h/L)	1.50 0.91	0.76 0.26
AUC (mg h/L)	1.61 0.92	0.83 0.27
(h)	1.70 0.24	1.7 0.2
(h)	0.48 0.29	0.36 0.07
CL/ [L/(h·kg)]	39 17	65 21
/ (L/kg)	97.5 47	154 33
(mg/L)	0.55 0.22	0.37 0.12
(L/h)	0.41 0.06	0.41 0.19

Significant difference or .