A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 41

Pharmacokinetic parameters of DCQA and caffeic acid after oral administration of A. fragrans to rats (dose 0.16 g/kg and ) [39].

Parameters	Caffeic acid	1,5-DCQA	3,4-DCQA	3,5-DCQA	4,5-DCQA
(h)	1.51 0.65	1.84 0.73	1.96 0.45	1.49 0.57	1.94 0.85
(h)	0.22 0.09	0.5 0.24	0.5 0.14	0.5 0.24	0.28 0.09
(ng/mL)	51.6 21.0	96.2 38.3	62.0 24.4	53.5 17.2	24.1 10.0
AUC (ng h/mL)	110.36 29.93	169.41 85.45	149.52 64.91	96.45 45.79	17.57 9.08
AUC (ng h/mL)	113.29 28.88	181.21 80.91	163.33 67.33	100.49 44.1	19.07 10.62
/ (mL/kg)	1.81 10^4  ±  0.52 10^4	6.53 × 10^4  ±  1.57 × 10^4	3.47 × 10^5  ±  0.76 × 10^5	4.29 × 10^5  ±  1.17 × 10^5	3.36 × 10^5  ±  8.84 × 10^4
CL/ (mL/kg/h)	7.72 10^3  ±  2.30 10^3	2.24 × 10^4  ±  8.42 × 10^3	1.18 × 10^5  ±  3.94 × 10^4	1.80 × 10^5  ±  7.88 × 10^4	5.43 × 10^5  ±  2.29 × 10^4
MRT (h)	5.95  ±  2.18	7.17  ±  1.11	9.27  ±  0.98	6.35  ±  1.1	10.21  ±  1.74
AUC/dose (ng·h/mL)	136.49  ±  34.79	50.2  ±  22.41	9.32  ±  3.84	6.36  ±  2.79	2.18  ±  1.21
/dose (ng/mL)	62.13  ±  37.39	26.65  ±  13.37	3.54  ±  1.39	3.39  ±  1.72	2.76  ±  1.49