Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 41
Pharmacokinetic parameters of DCQA and caffeic acid after oral administration of
A. fragrans to rats (dose 0.16 g/kg and
) [
39].
| Parameters | Caffeic acid | 1,5-DCQA | 3,4-DCQA | 3,5-DCQA | 4,5-DCQA |
| (h) | 1.51 0.65 | 1.84 0.73 | 1.96 0.45 | 1.49 0.57 | 1.94 0.85 | (h) | 0.22 0.09 | 0.5 0.24 | 0.5 0.14 | 0.5 0.24 | 0.28 0.09 | (ng/mL) | 51.6 21.0 | 96.2 38.3 | 62.0 24.4 | 53.5 17.2 | 24.1 10.0 | AUC (ng h/mL) | 110.36 29.93 | 169.41 85.45 | 149.52 64.91 | 96.45 45.79 | 17.57 9.08 | AUC (ng h/mL) | 113.29 28.88 | 181.21 80.91 | 163.33 67.33 | 100.49 44.1 | 19.07 10.62 | / (mL/kg) | 1.81 104 ± 0.52 104 | 6.53 × 104 ± 1.57 × 104 | 3.47 × 105 ± 0.76 × 105 | 4.29 × 105 ± 1.17 × 105 | 3.36 × 105 ± 8.84 × 104 | CL/ (mL/kg/h) | 7.72 103 ± 2.30 103 | 2.24 × 104 ± 8.42 × 103 | 1.18 × 105 ± 3.94 × 104 | 1.80 × 105 ± 7.88 × 104 | 5.43 × 105 ± 2.29 × 104 | MRT (h) | 5.95 ± 2.18 | 7.17 ± 1.11 | 9.27 ± 0.98 | 6.35 ± 1.1 | 10.21 ± 1.74 | AUC/dose (ng·h/mL) | 136.49 ± 34.79 | 50.2 ± 22.41 | 9.32 ± 3.84 | 6.36 ± 2.79 | 2.18 ± 1.21 | /dose (ng/mL) | 62.13 ± 37.39 | 26.65 ± 13.37 | 3.54 ± 1.39 | 3.39 ± 1.72 | 2.76 ± 1.49 |
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