Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 45
Pharmacokinetic parameters of 8-O-acetyl harpagide and harpagide in rats (
) [
42].
| | Compounds | Dose | (ng/mL) | (h) | (h) | AUC (h/ng/mL) | AUC (h/ng/mL) |
| | 8-O-Acetyl harpagide | 12 mg/kg | 1444.17 131.96 | 0.83 0.25 | 3.37 0.32 | 1635.03 102.18 | 1674.84 169.09 | | Harpagide (as a metabolite) | — | 189.04 17.34 | 1.00 0.05 | 2.58 0.16 | 684.11 99.37 | 1104.87 141.70 | | Harpagide | 3 mg/kg | 338.81 31.86 | 0.21 0.06 | 2.34 0.58 | 604.44 52.09 | 806.30 31.76 |
|
|
