A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 55

Pharmacokinetic parameters of cimicifugosides in rat plasma after i.v. administration of single cimicifugosides [51].

Dose (mg/kg)	Compound	AUC (pmol h/mL)	(h)	MRT (h)	(pmol/mL)	CL (mL/h kg)	(mL/kg)
5	A	484.9 203.4	1.13 0.53	0.39 0.16	1219 153.3	15.7 7.37	26.7 21.1
	B	17,100 4183	2.50 0.53	2.54 0.68	9106 692.9	0.48 0.14	1.77 0.79
	C	31,820 1741	5.69 1.29	9.74 1.07	6824 2267	0.24 0.01	1.98 0.44
	D	7924 3026	4.17 0.34	2.86 0.38	4682 943	1.13 0.42	6.75 2.25