New Journal of Science / 2016 / Article / Tab 6

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 6

Pharmacokinetic parameters of luteolin, apigenin, chrysoeriol, and diosmetin in rats after oral administration of 100 mg/kg FCE with or without coadministration of entacapone (20 mg/kg) [9].

ParametersApigeninLuteolin
FCEFCE + entacaponeFCEFCE + entacapone

AUC (mg/L·h)36.25 1654.39 243.971 1.25.862 1.4
MRT (h)9.46 1.19.25 0.92.589 0.512.585 0.52
(h)18.44 1210.98 5.22.805 0.96.671 7.4
CL/ (L/h/kg)0.0876 0.0600.06940 0.0461.515 0.450.818 0.51
/ (L/kg)2.497 1.51.305 0.95.975 2.14.598 2.8
(mg/L)3.310 0.734.567 1.51.684 0.212.466 0.69

ParametersChrysoeriolDiosmetin
FCEFCE + entacaponeFCEFCE + entacapone

AUC (mg/L·h)1.468 0.091.017 0.172.869 0.742.329 0.67
MRT (h)11.07 0.810.66 1.16.568 0.86.869 0.39
(h)26.24 929.80 367.359 1.57.566 1.6
CL/ (L/h/kg)1.790 0.601.587 0.91.773 0.542.133 0.50
/ (L/kg)61.84 1259.26 5018.37 5.223.58 9
(mg/L)0.0931 0.0280.06404 0.0250.3294 0.0520.3108 0.074

Data are expressed as mean SD, ; ; compared with the FCE group.