A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 8
Pharmacokinetic parameters of methoxyflavones after single oral and i.v. 250 mg/kg dose of KP in rats [11].
Parameters
Route
PMF
TMF
DMF
AUC (h·g/mL)
Oral
3.65 0.63
6.96 1.11
7.01 1.37
IV
76.77 19.50
275.66 86.06
233.48 71.57
(h)
Oral
3.12 1.34
5.04 1.10
5.85 1.72
IV
2.36 1.89
4.19 1.45
3.75 1.01
(h−1)
Oral
0.28 0.17
0.15 0.04
0.13 0.03
IV
0.61 0.22
0.32 0.12
0.32 0.11
CL (mL/h)
Oral
622.85 114.86
337.00 62.17
367.28 82.35
IV
21.56 7.18
6.30 2.17
7.98 2.34
(h)
Oral
1.71 0.36
0.85 0.40
0.76 0.40
(μg/mL)
Oral
0.55 0.05
0.88 0.11
0.78 0.11
(mL)
Oral
2637.13 846.59
2385.10 364.37
2957.53 458.19
(h−1)
Oral
1.23 0.54
8.53 3.64
8.69 2.33
Bioavailability (%)
—
3.32
1.75
2.10
LOD (g/mL)
—
0.19
0.09
0.93
LOQ (g/mL)
—
0.37
0.19
1.86
Data are expressed as mean SD (). IV, intravenous. Polyethylene glycol 400: significance higher than the others in the same route at . Significance lower than the others in the same route, . Significance lower than the other route.
