Table of Contents
Research Letters in Organic Chemistry
Volume 2008, Article ID 696090, 4 pages
Research Letter

A Novel, One-Step Palladium and Phenylsilane Activated Amidation from Allyl Ester on Solid Support

Department of Early Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543-4000, USA

Received 24 June 2008; Accepted 14 August 2008

Academic Editor: Dennis Hall

Copyright © 2008 Zheming Ruan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The direct conversion of solid-supported carboxylic acid allyl esters to carboxamides through the use of phenylsilane and catalytic Pd ( P P h 3 ) 4 under mild reaction conditions is reported. The use of this methodology for the generation of a 48 compound solid-phase array is described herein.