Table of Contents
Research Letters in Organic Chemistry
Volume 2008, Article ID 810678, 3 pages
Research Letter

A Novel and One-Pot Synthesis of 6-arylpyrimidin-4-ol

Drug Discovery Chemistry, Glenmark Research Centre, Glenmark Pharmaceuticals Limited, MIDC, Mahape, Navi Mumbai 400709, India

Received 25 June 2008; Accepted 2 November 2008

Academic Editor: William Ogilvie

Copyright © 2008 Jitendra M. Gajera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have developed a novel and one-pot synthesis of 6-arylpyrimidine-4-ol by reacting commercially available alkyl 3-oxo-3-arylpropanoate with formamide in the presence of stoichiometric amount of ammonium acetate.