Solvent-Free Microwave Synthesis of Aryloxypropanolamines by Ring Opening of Aryloxy Epoxides

Table 1

Ring opening of 3-(1-naphthoxy)-1,2-epoxy propane 1a with isopropylamine 2 under different conditions (3-(1-naphthoxy)-1,2-epoxypropane (1.0 g, 5 mmol) and isopropylamine (0.59 g, 7.5 mmol) were heated at 50^°C in a Teflon reactor for the given time under specified MW power).

Entry	Conditions	Yield^(a) (%)
1^(b)	Without MW	90
2	2 min/100 W	45
3	2 min/300 W	56
4	2 min/400 W	64
5	5 min/100 W	69
6	5 min/400 W	75
7	10 min/100 W	67
8	10 min/300 W	85
9	10 min/400 W	98

^(a) Isolated yield after chromatographic separation.
^(b) Reaction carried out for 16 hours.