Directed Metalation of Heterocycles, 5-Methoxy-2-phenyloxazol-4-yllithium: An Approach to ,-Dehydroamino Acids
Scheme 2
Addition of the oxazolyllithium I to benzaldehyde and iso-butyraldehyde to form the alcohols 3, and their acid catalyzed rearrangement, ring cleavage, and hydrolysis to furnish the corresponding N-benzoyl dehydroamino acids 5.