Table of Contents
Organic Chemistry International
Volume 2011, Article ID 325291, 5 pages
http://dx.doi.org/10.1155/2011/325291
Research Article

RuCl3 · nH2O as Catalyst for Diastereoselective Direct Aldol Reaction: An Efficient Route to Hormone Steroid Derivatives

Department of Chemistry, Faculty of Science, The University of Guilan, P.O. Box 41335-1914, Rasht, Iran

Received 10 September 2010; Accepted 30 November 2010

Academic Editor: Chao Jun Li

Copyright © 2011 Khalil Tabatabaeian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

R u I I I -catalyzed regio- and diastereoselective direct aldol reaction of progesterone with aromatic aldehydes has been developed in good yields (58–78%). Advantages of this method include catalytic efficiency, short reaction times, and ease of operation and workup.