Organic Chemistry International
Volume 2011, Article ID 325291, 5 pages
http://dx.doi.org/10.1155/2011/325291
Research Article
RuCl3 · nH2O as Catalyst for Diastereoselective Direct Aldol Reaction: An Efficient Route to Hormone Steroid Derivatives
Department of Chemistry, Faculty of Science, The University of Guilan, P.O. Box 41335-1914, Rasht, Iran
Received 10 September 2010; Accepted 30 November 2010
Academic Editor: Chao Jun Li
Copyright © 2011 Khalil Tabatabaeian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
-catalyzed regio- and diastereoselective direct aldol reaction of progesterone with aromatic aldehydes has been developed in good yields (58–78%). Advantages of this method include catalytic efficiency, short reaction times, and ease of operation and workup.