Table of Contents
Organic Chemistry International
Volume 2011 (2011), Article ID 389615, 7 pages
http://dx.doi.org/10.1155/2011/389615
Research Article

Synthesis and Characterization of a New Five and Six Membered Selenoheterocyclic Compounds Homologues of Ebselen

1Department of Chemistry, Taibah University, P.O. Box 30002, Madinah, Saudi Arabia
2Services Généraux (Faculté des Sciences) Relations Académiques et Scientifiques (Sciences), University of Liege, allée de la Chimie 3, 4000 Liège 1, Belgium

Received 8 October 2011; Revised 18 December 2011; Accepted 27 December 2011

Academic Editor: Kirpal Bisht

Copyright © 2011 Mouslim Messali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The discovery of the antioxidant activity of selenoenzyme glutathione peroxidase (GPx) has attracted growing attention in the biochemistry of selenium. Among molecules which mimic the structure of the active site of the enzyme, N-phenyl-1,2-benzisoselenazolin-3-one 1, Ebselen, exhibited useful anti-inflammatory properties. It has been extensively investigated and has undergone clinical trials as an anti-inflammatory agent. Unfortunately, Ebselen exhibits relatively poor catalytic activity, prompting attempts to design more efficacious GPx mimetics that would retain his low toxicity while manifesting improved catalytic properties. In this context, novel 1,2-benzoselenazine and 1,2-benzoselenazols, which are five and six membered homologues of Ebselen were synthesized and characterized. One structure has been proven by single crystal X-ray crystallography.