Table of Contents
Organic Chemistry International
Volume 2011 (2011), Article ID 753142, 4 pages
http://dx.doi.org/10.1155/2011/753142
Research Article

Melamine Nitrate: A Novel and Efficient Reagent for Regioselective Nitration of Phenols

Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan, Hubei 430070, China

Received 2 April 2011; Accepted 5 May 2011

Academic Editor: Feihe Huang

Copyright © 2011 Yong-qiang Chen and Hong Jiang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

General Procedure for the Nitration of Phenols:

In a typical nitration procedure, to a stirring mixture of acetone (15 mL) and phenol (0.56 g, 6 mmol) at room temperature, MN (1.3 g, 7 mmol) and the catalytic amount of p-toluenesulfonic acid (0.06 g, 0.4 mmol) were added. The mixture was stirred at room temperature for appropriate time. The progress of the reaction was monitored by TLC. At the end of the reaction, the mixture was filtered. Then, acetone was removed by evaporation to afford the crude product, which was chromatographed over silica gel to give the pure compound in high yield using hexane : ethyl acetate as eluents. Other nitro phenolic compounds were prepared similarly. The compounds were confirmed by 1H NMR, MS and IR spectrum as follows.

  1. Supplementary Material