2-Pyrrolidinones and 3-Pyrrolin-2-ones: A Study on the Chemical Reactivity of These Structural Moieties

<table>Reagents and conditions: (a) (i) TMSCl (2.0 equiv), r.t. (10 min), (ii) PhMgBr (1.5 equiv), CuBr·SMe<sub>2</sub> (0.2 equiv), THF (−78°C, 3 h); (b) H<sub>2</sub> (balloon), 20% Pd(OH)<sub>2</sub>/C (0.1 equiv), MeOH (r.t., 12 h); (c) <i>S</i>-<i><i>α</i></i>-methylbenzylamine (6.5 equiv), r.t. (72 h).</table>

Organic Chemistry International

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Scheme 4

Scheme 4: 2-Pyrrolidinones and 3-Pyrrolin-2-ones: A Study on the Chemical Reactivity of These Structural Moieties 