Table of Contents
Organic Chemistry International
Volume 2011, Article ID 980765, 7 pages
Research Article

Copper(I)-BINOL Catalyzed Domino Synthesis of 1,4-Benzoxathiines through 𝐂 ( 𝐚 𝐫 𝐲 𝐥 ) -O Bond Formation

Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India

Received 1 March 2011; Revised 29 April 2011; Accepted 13 June 2011

Academic Editor: Ashraf Aly Shehata

Copyright © 2011 Chiranjeevi Korupalli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


1,4-benzoxathiine moieties can be synthesized by domino S N 2 ring opening of epoxide with o-halothiophenols followed by the copper(I)-BINOL catalyzed Ullmann-type coupling cyclization (intramolecular C ( a r y l ) -O bond formation) with moderate to good yields.