A Solvent-Free Protocol for the Green Synthesis of 5-Arylidene-2,4-thiazolidinediones Using Ethylenediamine Diacetate as Catalyst

Table 1

Effect of different reaction conditions on EDDA catalyzed synthesis of 5-benzylidene-2,4-thiazolidinedione^a.

Entry	Temperature (°C)	Catalyst (mol%)	Time (min)	Yield^b (%)
1	30	10	150	63
2	40	10	85	77
3	50	10	35	82
4	60	10	15	80
5	70	10	7	90
6	80	10	3	91
7	90	10	3	89
8	80	—	3	—
9	80	3	3	76
10	80	5	3	91
11	80	20	3	88

^aReaction condition: benzaldehyde (10 mmol), 2,4-thiazolidinedione (10 mmol), in presence of EDDA under solvent-free conditions.
^bIsolated yield.