Table of Contents
Organic Chemistry International
Volume 2012, Article ID 278741, 6 pages
http://dx.doi.org/10.1155/2012/278741
Research Article

Synthesis and Characterization of N1-Phenylhydrazine-1,2-bis(carbothioamide) and Its Evaluation for Antimicrobial, Antioxidant, and Brine Shrimp Lethality Bioassay

1Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
2Department of Pharmacutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh

Received 6 March 2012; Revised 25 May 2012; Accepted 25 May 2012

Academic Editor: William N. Setzer

Copyright © 2012 G. M. Golzar Hossain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The compound 𝑁 1 -phenylhydrazine-1,2-bis(carbothioamide) was synthesised from phenylisothiocyanate reacting with thiosemicarbazide refluxing the mixture in ethanol. The new compound obtained was characterised by various spectral and elemental analyses. It was subjected to antibacterial, antioxidant and brine shrimp lethality bioassay. The compound showed brine shrimp lethality with LC50 value of 12.79 μg which was comparable to vincristine with LC50 value of 0.33 μg. The compound did not exhibit any antimicrobial activity against Gram +ve and Gram −ve organisms, as well as against the tested fungal strains. But very good free radical scavenging activity was observed at concentration range of 0.185–100 μg with IC50 values of 1.43 μg in comparison to reference standard butylated hydroxytoluene (BHT) with IC50 value 16.46 μg.