Table of Contents
Organic Chemistry International
Volume 2012 (2012), Article ID 282137, 7 pages
http://dx.doi.org/10.1155/2012/282137
Research Article

Polycations XX: New Monodentate Cationic Ligands and Their Coordination with Ruthenium for the Construction of Complexes Expressing Enhanced Interaction with DNA

Department of Chemistry and Biochemistry, Queens College, the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA

Received 3 July 2012; Revised 24 August 2012; Accepted 26 August 2012

Academic Editor: William Setzer

Copyright © 2012 Leslie Babukutty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prior investigations from this laboratory concerned with the preparation of new types of organic cations for a variety of biological and nonbiological applications have been extended to the preparation of cation-bearing ligands with nitrogen coordinating sites for use in complexation reactions with ruthenium cores. The syntheses of new cationic ligands as well as ruthenium complexes bearing them are reported here. The introduction of these new types of ligands is intended to provide to the complexes an enhanced ability to interact with DNA, and thereby to have the potential to be enhanced antitumor agents. Preliminary observations of their interactions with DNA are presented.