Table of Contents
Organic Chemistry International
Volume 2012, Article ID 284947, 4 pages
Research Article

Synthesis and Reactions of 3-(2-Chloromethyl-carbonylamino)tetrachloroquinazolin-2,4-dione

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, Arish, Egypt
2Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt

Received 16 April 2012; Accepted 4 June 2012

Academic Editor: Cyril Parkanyi

Copyright © 2012 M. A. Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of tetrachloroquinazolin-2,4-dione derivatives were synthesized using appropriate synthetic route and characterized by IR, 1H NMR, MS, and elemental analysis. The synthesized compounds were evaluated for their preliminary in vitro antibacterial activity towards Salmonella typhi, Staphylococcus aureus, and Bacillus cereus.