Organic Chemistry International / 2012 / Article / Tab 3

Research Article

An Expeditious and Safe Synthesis of Some Exocyclic α,β-Unsaturated Ketones by Microwave-Assisted Condensation of Cyclic Ketones with Aromatic Aldehydes over Anhydrous Potassium Carbonate

Table 3

Microwave-assisted condensation of cycloalkanones with aromatic aldehydes and cinnamaldehyde over anhy. K2CO3.

EntryKetone (1)Ar of aldehydeTime (min.)Product (5)Yield (%)M.P
Obs. (Lit.) [Reference]

4aC6H51.55a85190
(190) [64]
4a4-MeO–C6H41.55b78215
(215) [64]
4a4-Cl–C6H41.55c86228-229
(229-230) [64]
4aE-C6H5CH=CH–1.55d87220
(220-221) [64]
4bC6H51.55e82155
(155) [64]
4b4-MeO–C6H41.55f78213
(213) [64]
4b4-Cl–C6H41.55g88141-142
(138) [64]
4bE-C6H5CH=CH–1.55h82176-177
(178) [64]
4cC6H51.55i85108
106.5–108 [65]
4cE-C6H5CH=CH–1.55j81204–206
207-208 [65]

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