Journals
Publish with us
Publishing partnerships
About us
Blog
Organic Chemistry International
Table of Contents
Organic Chemistry International
/
2012
/
Article
/
Tab 2
/
Research Article
Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition
Table 2
Optimization of reaction condition for the N-arylation of 1,2,4-triazole with iodobenzene.
Entry
Solvent
Base
Reaction time (h)
(Isolated yield)
a
1
Toluene
K
2
CO
3
12
65%
2
CH
3
CN
K
2
CO
3
12
40%
3
CH
3
OH
K
2
CO
3
12
25%
4
CHCl
3
K
2
CO
3
12
15%
5
DMF
K
2
CO
3
2
84%
6
DMF
K
2
CO
3
8
84%
7
DMF
CS
2
CO
3
5
45%
8
DMF
t-BuONa
5
55%
9
DMF
NaOH
5
35%
10
DMF
Rb
2
CO
3
4
75%
a
Isolated yield.