Table of Contents
Organic Chemistry International
Volume 2012, Article ID 956584, 5 pages
Research Article

Regioselective Syntheses of 3-Benzyl-Substituted 7H-Thiazolo[3,2-a]pyrimidine-7-ones through Palladium-Catalyzed Heteroannulation of Acetylenic Compounds

School of Chemistry, Shahrood University of Technology, Shahrood 3619995161, Iran

Received 8 June 2012; Revised 2 August 2012; Accepted 5 August 2012

Academic Editor: Dipakranjan Mal

Copyright © 2012 Mohammad Bakherad and Farzaneh Gholipoor. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient synthesis of 3-benzyl-substituted 7H-thiazolo[3,2-a]pyrimine-7-ones in acetonitrile is accomplished via Pd- and Cu-catalyzed reaction of 2-mercaptopropargylpyrimidone with various aryl iodides in the presence of triethylamine as the base.