Table of Contents
Organic Chemistry International
Volume 2013 (2013), Article ID 259348, 9 pages
Research Article

Utility of Activated Nitriles in the Synthesis of Novel Heterocyclic Compounds with Antitumor Activity

Department of Chemistry, Faculty of Science, Al-Azhar University, Girls' Branch, Nasr City, Cairo, Egypt

Received 23 July 2013; Accepted 19 August 2013

Academic Editor: Joseph E. Saavedra

Copyright © 2013 Asmaa S. Salman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Reaction of cyanoacetic acid hydrazide (1) with 4-methoxyacetophenone and 4-chlorobenzaldehyde (2a,b) afforded the corresponding 2-cyanoacetohydrazide derivatives (3a,b) respectively. The latter compounds were utilized as a key intermediate for the synthesis of new heterocyclic compounds. Newly synthesized compounds were characterized by elemental analyses and spectral data. The antitumor evaluation of some newly synthesized compounds was screened in vitro against human breast cancer cell line (MCF-7).