Research Article
An Efficient and Green Method for Synthesis of 2,4,5-Triarylimidazoles without Use of Any Solvent, Catalyst, or Solid Surface
Table 1
Synthesis of 2,4,5-triarylimidazoles (3) under catalyst-free and solvent-free conditions.
| Entry | Starting materials | Product | Time (h) | Yield (%) |
M. P. (Lit.) reference | 1 with Ar1 = | 2 with Ar2 = |
| 1 | C6H5 | C6H5 | 3a | 3 | 80 | 272-273 (272–274) [19] | 2 | C6H5 | 4-CH3-C6H4 | 3b | 3 | 75 | 227-228 (227-228) [19] | 3 | C6H5 | 4-Cl-C6H4 | 3c | 3 | 78 | 261-262 (261-262) [19] | 4 | C6H5 | 4-Br-C6H4 | 3d | 3 | 81 | 245-246 (244–246) [19] | 5 | C6H5 | 4-CH3O-C6H4 | 3e | 3 | 76 | 226-227 (227-228) [19] | 6 | C6H5 | 3,4-(OCH2O)C6H3 | 3f | 3 | 73 | 248–250 (248–250) [19] | 7 | C6H5 | 3-O2N-C6H4 | 3g | 3 | 90 | >300 (>290) [19] | 8 | C6H5 | 4-(CH3)2N-C6H4- | 3h | 3 | 45 | 256–258 (257-258) [19] | 9 | C6H5 | 3-CH3O,4-HO-C6H3- | 3i | 5 | 67 | 165–167 (166) [28] | 10 | C6H5 | 2-Thienyl | 3j | 4 | 67 | 261–263 (260–262) [29] | 11 | C6H5 | 3-Pyridyl | 3k | 3 | 66 | 245–247 (244–246) [30] | 12 | 4-CH3-C6H4- | C6H5 | 3l | 5 | 59 | 252-253 (254) [31] | 13 | 4-CH3-C6H4- | 4-Cl-C6H4 | 3m | 5 | 64 | 262-263 (263-264) [32] | 14 | 4-CH3-C6H4- | 4-CH3O-C6H4 | 3n | 6 | 61 | 250-251 (250-251) [33] |
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