Table of Contents
Organic Chemistry International
Volume 2013 (2013), Article ID 631723, 8 pages
Research Article

Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity

1Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India
2PG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 570025, India

Received 1 April 2013; Revised 13 September 2013; Accepted 13 September 2013

Academic Editor: Ashraf Aly Shehata

Copyright © 2013 Kikkeri P. Harish et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The synthesis of new pyrazine substituted 1,3,4-thiadiazole derivatives was carried out in good yield by the reaction of pyrazine substituted 1,3,4-thiadiazoles with various sulfonyl chlorides. A chemical structure of all the new compounds was confirmed by 1H NMR and mass spectral data. The new compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method. Rotarod method was employed to determine the neurotoxicity. Few compounds showed significant changes in anticonvulsant activity. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg).