Synthesis of Pyrazine Substituted 1,3,4-Thiadiazole Derivatives and Their Anticonvulsant Activity

Table 3

Neurotoxicity screening of the compounds 7(a–o).

Compound	Neurotoxicity screen
	0.5 h	1 h	2 h	4 h
7a	0/4	0/4	0/4	0/4
7b	0/4	0/4	0/4	0/4
7c	0/4	0/4	1/4	1/4
7d	0/4	0/4	0/4	0/4
7e	0/4	0/4	0/4	0/4
7f	0/4	0/4	0/4	0/4
7g	0/4	0/4	0/4	0/4
7h	0/4	0/4	1/4	1/4
7i	0/4	0/4	0/4	0/4
7j	0/4	0/4	0/4	0/4
7k	0/4	0/4	0/4	0/4
7l	0/4	0/4	1/4	1/4
7m	0/4	0/4	0/4	0/4
7n	0/4	0/4	0/4	0/4
7o	0/4	0/4	0/4	0/4
Standard	0/4	0/4	0/4	0/4

The data in the table represent the ratio between the numbers of the animals that exhibited neurotoxicity against the number of tested animals.