Green Chemical Synthesis and Analgesic Activity of Fluorinated Thiazolidinone, Pyrazolidinone, and Dioxanedione Derivatives

Table 2

Synthesis of 5-benzylidene-2-thioxo-1,3-thiazolidin-4-one (3a) under different solvents.

Entry	Catalyst	Solvent/temperature (°C)	Time (hrs)	Yield (%)
1	Lemon juice	EtOH/78	4	75
2	Lemon juice	CH3OH/65	4	72
3	Lemon juice	CH2Cl2/40	5	66
4	Lemon juice	Room temperature	1.5	92