Green Chemical Synthesis and Analgesic Activity of Fluorinated Thiazolidinone, Pyrazolidinone, and Dioxanedione Derivatives

Table 7

Analgesic activity of the fluorinated 5-Substitutedbenzylidene derivatives.

	0 min	30 min	60 min	90 min
Control	1.33±0.210	1.66±0.210	1.50±0.223	1.83±0.307
Standard Drug	1.5±0.223	3.5±0.428^∗∗; 53%	7.83±0.477^∗∗; 81%	13.16±0.166^∗∗; 86%
3a	1.16±0.166	2±0.258^ns; 17%	2±0.258^ns; 25%	2.56±0.210^ns; 27%
3b	1.66±0.210	3.16±0.307^∗∗; 48%	4.83±0.307^∗∗; 69%	9.66±0.557^∗∗; 81%
3d	1.66±0.166	1.83±0.307^ns; 9%	2±0.258^ns; 25%	2.56±0.210^ns; 27%
5b	1.5±0.223	3.16±0.307^∗∗; 48%	5.5±0.223^∗∗; 73%	10.83±0.600^∗∗; 83%
5d	1.66±0.210	3.0±0.0.258^∗∗; 45%	4.5±0.428^∗∗; 67%	8.52±0.670^∗∗; 78%

All values mean ± S.E.M values using 6 animals in each group.
Significant differences with respect to control group were evaluated by ANOVA, Dunnett’s test.
* 𝑃<0.05,**𝑃<0.01, ***𝑃<0.001, ns: nonsignificant.